Cancer treatment has seen many paradigm change in the last 10 years. From the point where we used to offer maximal tolerable doses to now when more and more studies are favoring de-escalation of duration as well as dose. For example for a low risk colon cancer now we are offering only three to four months of chemotherapy, while previously six months of perioperative chemotherapy was compulsory. This de-escalation treatment has not only reduced toxicity but also leaves us wi