When multiple myeloma returns, choosing the right next-line therapy requires specialized expertise. A second opinion from a myeloma-focused center helps confirm your treatment plan, explore clinical trials, and access novel therapies like CAR-T. Key Takeaways Second opinions for relapsed myeloma are most valuable from dedicated myeloma programs at academic centers with high case volume and clinical trial portfolios US centers like Mayo Clinic, Dana-Farber, and Cleveland Clini