TL;DR: What to Do When Chemotherapy Doesn't Work for Mouth Cancer When first-line chemotherapy fails, immunotherapy drugs like pembrolizumab have shown response rates in patients with oral cancer, particularly those with PD-L1 positive tumors [1] Dr. Bharat Patodiya precision oncology approach includes comprehensive biomarker testing to identify treatment resistance mechanisms and guide second-line therapy selection Targeted therapies, clinical trials, and combination treatme