Asciminib
Asciminib is a tablet taken by mouth that works as an inhibitor of a protein called BCR-ABL1. It specifically targets a part of the protein called the ABL myristoyl pocket (STAMP). Normally, this pocket is occupied by another part of the protein to keep it inactive. However, when BCR and ABL1 are fused together, this part is lost, leaving the ABL1 kinase active. Asciminib binds to this empty pocket and blocks the activity of the kinase, which helps stop the growth of tumor cells. It works against both the normal form of the protein and mutated versions, including the T315I mutation.
Have any queries, book a consultation with our Oncology Clinical SpecialistPrimary uses are to treat Leukemia, Chronic myelogenous.
Research studies are going on this drug to check if this medicine can be used to treat other type of cancer.
Visit our Research Division Doctors in Online Consults for more details.
If you miss a dose of asciminib:
- If you take asciminib once daily: take it as soon as you can if it is within 12 hours of the missed dose. If it is more than 12 hours since your missed dose, skip the missed dose and take the next dose as scheduled. o
- If you take asciminib two times daily: take it as soon as you can if it is within 6 hours of the missed dose. If it is more than 6 hours since your missed dose, skip the missed dose and take the next dose as scheduled.
- If you vomit the dose of asciminib within 1 hour of taking it, do not take a second dose. Call your healthcare team during office hours for advice. You will be told whether you need to take another dose.
Have any queries, book a consultation with our Oncology Clinical Specialist
Anemia, Low immunity, Low lymphocyte (a kind of white blood cells) count, Low platelet count, Low white blood cell count, Heart problems, Abdominal pain, Diarrhea, Nausea, Fatigue, Hypersensitivity, High amylase (type of enzyme) levels, Liver enzyme increase.
Have any queries, book a consultation with our Oncology Clinical Specialist
Other drugs such as Warfarin and Repaglinide may interact with asciminib. Tell your doctor if you are taking these or any other drugs as you may need extra blood tests or your dose may need to be changed.
Have any queries, book a consultation with our Oncology Clinical Specialist
Asciminib may affect fertility in men and women. If you plan to have children, discuss this with your doctor before being treated with asciminib.
Asciminib may damage sperm and harm the baby if used during pregnancy. It is best to use birth control while being treated with asciminib and for at least 1 week after your treatment has ended. Tell your doctor right away if you or your partner becomes pregnant. Breastfeeding is not recommended during treatment and for at least 1 week after treatment
Have any queries, book a consultation with our Oncology Clinical Specialist
