Chlorambucil

Chlorambucil is a tablet that you take by mouth. It works as follows:- 

Chlorambucil is a medication derived from nitrogen mustard and works by disrupting the cell cycle without specifically targeting any particular phase. It acts as a powerful alkylating agent, meaning it attaches alkyl groups to cellular components. This process forms a highly reactive compound that likely leads to cross-linking between DNA strands, disrupting the synthesis of DNA, RNA, and proteins. Additionally, chlorambucil has immunosuppressive properties, mainly by suppressing the activity of lymphocytes.

Have any queries, book a consultation with our Oncology Clinical Specialist

Primary uses are to treat Chronic lymphocytic leukemia, Hodgkin’s lymphoma, Non-Hodgkin’s lymphoma.

Secondarily this drug is also used to treat Gestational trophoblastic tumour, Ovarian cancer.

Research studies are going on this drug to check if this medicine can be used to treat other type of cancer. 

Visit our Research Division Doctors in Online Consults for more details.

For continuous once daily dosing: If you miss a dose of chlorambucil, take it as soon as you can if it is within 12 hours of the missed dose. If it is over 12 hours since your missed dose, skip the missed dose and go back to your usual dosing times. Call your doctor during office hours to ask about making up the missed dose.

If you vomit right after taking the medication, call your doctor.

 

Have any queries, book a consultation with our Oncology Clinical Specialist 

Skin allergies have occurred following initial or subsequent dosing, Shortage of red blood cells in body, Low immunity, Low lymphocyte (kind of white blood cells) count, Low platelet count, Low immunity.

 

Have any queries, book a consultation with our Oncology Clinical Specialist

There are no known drug interactions with chlorambucil. 

Research studies are going on this drug to check if this medicine interacts with other medications.

Visit our Research Division Doctors in Online Consults for more details.

 

 

Chlorambucil may cause sterility in men and menopause in women. If you plan to have children, discuss this with your doctor before being treated with chlorambucil.

Chlorambucil may damage sperm and may harm the baby if used during pregnancy. It is best to use birth control while being treated with chlorambucil. Tell your doctor right away if you or your partner becomes pregnant. Do not breast feed during treatment

 

Have any queries, book a consultation with our Oncology Clinical Specialist